Hyaluronic acid Methacryloyl (HAMA)

Hyaluronic acid Methacryloyl, HAMA EFL-HAMA-150K/400K. The kit includes Hyaluronic acid methacryloyl and photoinitiator LAP. All products in the HAMA range can be used in cell culture, biological 3D p

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product introduction

Hyaluronic acid (HA) is a natural glycosaminoglycan polymer consisting of aldehyde-D-glucuronic acid and N-Acetyl-D-Glucosamine as disaccharide structural units. It is a component of the extracellular matrix of animal tissues and has good moisture retention properties. Its content is high in brain tissue, synovial fluid, and vitreous body. HA plays an important role in many biological processes such as cell proliferation, differentiation, morphogenesis, inflammation, and wound healing.

Hyaluronic acid Methacryloyl(HAMA)can be photo-crosslinked by grafting methyl propene group on the molecular chain of hyaluronic acid. The HAMA product launched by the EFL team can be cured into gel within 10 seconds under visible light irradiation. It has good biocompatibility, and strong material scalability, and can provide a variety of viscoelastic properties to adapt to different applications.


Item】

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Applications】

Cell culture, biological 3D printing, tissue engineering, etc.


Storage】

Dry kit: room temperature, 3 months; 4℃, 12 months; -20℃, 18 months.


HNMR】Synthesis reaction mechanism of HAMA and NMR spectrum of EFL-HAMA-150K/400K

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Rheological property】

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Rheological properties of different concentrations of EFL-HAMA-150K: (A) photocrosslinking process; (B) storage modulus G’ after curing; (C, D) viscosity

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Rheological properties of different concentrations of EFL-HAMA-400K: (A) photocrosslinking process; (B) storage modulus G’ after curing; (C, D) viscosity

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Compression characteristic】Compression characteristics of different concentrations of EFL-HAMA (UV405nm, 30Mw/cm2, 30sd) :(A,C) stress-strain curves; (B,D) Compression modulus


Biocompatibility】3D cell culture on EFL-HAMA hydrogels:ADTC5 Live/Dead Cell Staining

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3D printing performance】HAMA hydrogel structure printed by the photocure bio-3D printer (EFL-BP-8600)

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【Product Manual】-【EFL-HAMA series】-Hyaluronic acid Methacryloyl 

【Product Manual】-【EFL-HAMA  series HAMA-150K 2.5g HAMA-400K 1g No Initiator】-Hyaluronic acid Methacryloyl

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