Introduction: The team of Prof. Qianbing Wan and Jian Wang at Sichuan University prepared 3D printed porous composite scaffolds loaded with nanoscale ZIF-8, a MOF material, and investigated the mechanical properties, biocompatibility, and osteogenic properties of the composite scaffolds in vivo and in vitro, and demonstrated their feasibility for bone defect repair. The related paper "3D printing ofmetal-organic framework incorporated porous scaffolds to promote osteogenic di The paper, "3D printing ofmetal-organic framework incorporated porous scaffolds to promote osteogenic differentiation and bone regeneration," was published in the journal Nanoscale.
Link to original article：https://doi.org/10.1039/D0NR06297A
Introduction: Riccardo Levato's team at Utrecht University, The Netherlands, combined near-field direct writing and extrusion printing techniques integrating hydrogel, ceramic and polymer materials to fabricate a bio-ceramic ink based on mineral phase calcium phosphate (CaP) developed to mimic skeletal muscle into a subchondral bone substitute using extrusion printing. Polymer lattices were prepared using near-field direct writing immobilized in the ceramic ink and embedded with cell-laden GelMA as the cartilage component. Several microfibrous structures were investigated as cross-linking agents to enhance the bonding of the hydrogel-ceramic interface and to enhance the compressive properties of the hydrogel. The paper "Combiningmulti-scale 3D printing technologies to engineer reinforced hydrogel-ceramic interfaces" was published in the journal Biofabrication.
Link to original article：https://doi.org/10.1088/1758-5090/ab69d9
Introduction: Luiz E. Bertassoni's team at Oregon Health & Science University developed a collagen hydrogel loaded with human mesenchymal stem cells (hMSCs) and promoted protein-induced collagen fibril mineralization by adding soluble Ca2+, PO43-, and nucleation inhibitor-osteobridge protein (mOPN) to mimic the intrafibrillar and extrafibrillar nanomineralization profiles of natural bone. The constructed microenvironment itself was shown to be sufficient to stimulate the osteogenic differentiation of hMSCs and also to form hMSCs-supported capillaries in vitro and in vivo. The related paper "Rapid fabrication of vascularized and innervated cell-laden bonemodels with biomimetic intrafibrillar collagen mineralization " was published in the journal Nature Communications.
Link to original article：https://doi.org/10.1038/s41467-019-11455-8
Introduction: The group of Prof. Fan Shunwu and Dr. Lin Xianfeng at Zhejiang University prepared a decellularized periosteal-derived extracellular matrix (PEM) hydrogel based on the Voytik-Harbin method and evaluated its immunomodulatory effects at different times in the bone repair process. The paper, "Periostea lmatrix-derived hydrogel promotes bone repair through an early immune regulation coupled with enhanced angio- and osteogenesis" was published in the journal Biomaterials.
Link to original article：https://doi.org/10.1016/j.biomaterials.2019.119552
Introduction: The team of Prof. Wenguo Cui from Shanghai Jiao Tong University and Prof. Liang Chen from Soochow University have constructed a composite structured bionanocardial membrane with sustained releasing VEGF by combining microsol electrostatic spinning and collagen self-assembly technology. The related research paper, "Hierarchical micro/nanofibrous membranes of sustained releasing VEGF for periosteal regeneration," was published in the journal Biomaterials.
Link to original article：https://doi.org/10.1016/j.biomaterials.2019.119555
Introduction: Based on DLP printing technology, Prof. Cheng-Tie Wu's team at Shanghai Institute of Silicate, Chinese Academy of Sciences has successfully prepared a bionic bone scaffold with a complete hierarchical Hafers bone structure and achieved better control of the compressive strength and porosity of the scaffold by changing the parameters of the Hafers bionic structure. Its multicellular delivery capability was demonstrated in the induction of osteogenesis, angiogenesis and neurogenic differentiation in vitro, and the promotion of vascular growth and new bone formation in vivo. A related paper, "3D printing of Haversian bone-mimicking scaffolds formulticellular delivery in bone regeneration," was published in the journal Science Advances. in the journal Science Advances.
Link to original article：https://doi.org/10.1126/sciadv.aaz6725
Introduction: Alireza Moshaverinia's team at the University of California used double-bonded and dopamine-modified sodium alginate to prepare an adhesive hydrogel, which was modified with RGD peptides to further enhance the biocompatibility of the gel. The gel was able to achieve light-induced chemical cross-linking, filling of complex bone defect trauma and good interfacial adhesion. The paper, "An engineered cell-laden adhesive hydrogel promotes craniofacial bone tissue regeneration in rats," was published in the journal Science Translational Medicine.
Link to original article：https://doi.org/10.1126/scitranslmed.aay6853
INTRODUCTION: Professor Min Lee's team at the University of California, USA, designed an alternative strategy for producing exosome-associated vesicles with high yields while improving regenerative capacity by employing an extrusion method to accumulate exosome mimics (EMs) from human mesenchymal stem cells (hMSCs). By applying hMSC-EMs together with injectable chitosan hydrogels to unhealed mouse skull defects, excellent bone repair performance was demonstrated. The paper "Generation of Small RNA-Modulated Exosome Mimetics for Bone Regeneration" was published in the journal ACS Nano.
Link to original article：https://doi.org/10.1021/acsnano.0c05122
Introduction: Professor CedryckVaquette's team at the University of Queensland, Australia, in collaboration with Professor Yin Xiao's team at Queensland University of Technology, prepared GelMA bioinks containing patient autologous bone particles (BPs) to establish a personalized bone regeneration strategy using 3D bioprinting technology. The study showed that the composite bioink loaded with patient's autologous BPs could successfully print bone tissue scaffolds with relevant biological functions. The related paper "Patient-Specific Bone Particles Bioprinting for Bone Tissue Engineering" was published in the journal Advanced Healthcare Materials.
Link to original article：https://doi.org/10.1002/adhm.202001323
Introduction: Professor Min Lee's team at the University of California has designed a nanoclay-organic hydrogel bone sealant (NoBS) that integrates multiple physicochemical elements of bone regeneration into the same system. Among others, the assembly of plant compound-modified chitosan and silica-rich inorganic nanoclay serves as an extracellular matrix mimic for biocompatibility and osteoconductivity. The related paper "Inspired by Nature: FacileDesign of Nanoclay-Organic Hydrogel Bone Sealant with Multifunctional Properties for RobustBone Regeneration" was published in the journal Advanced Functional Materials.
Link to original article：https://doi.org/10.1002/adfm.202003717
Introduction: The team of Prof. Qin Shi from Soochow University and Prof. Wenguo Cui from Shanghai Jiao Tong University prepared GelMA-c-OGP hydrogel by co-cross-linking GelMA and double-bonded modified bone growth peptide (OGP), which can maintain the activity of OGP for a longer period of time and has good osteogenic activity and osteogenic ability in vitro and in vivo. The related paper "Gelatin Templated Polypeptide Co-Cross-Linked Hydrogel for Bone Regeneration" was published in the journal Advanced Healthcare Materials.
Link to original article：https://doi.org/10.1002/adhm.201901239
Introduction: Xuetao Shi's team at South China University of Technology (SCUT) formed a cartilage-mimetic scaffold (CS) by encapsulating kartogenin (KGN) with isocyanoacrylate modified β-cyclodextrin (β-CD-AOI) and compounding it into a methacrylate-hyaluronic acid (HAMA) hydrogel. The hydrogel was compounded on top of a premineralized 3D-printed porous scaffold to prepare a bionic biphasic osteochondral scaffold (BBOS), which can be used for repair of defects at the bone-chondral level. The related paper, "A Biomimetic Biphasic Osteochondral Scaffold with Layer-Specific Releaseof Stem Cell Differentiation Inducers for the Reconstruction of Osteochondral Defects" was published in the journal Advanced Healthcare Materials.
Link to original article：https://doi.org/10.1002/adhm.202000076
Introduction: Professor David Weitz's team at Harvard University and Professor Wenguo Cui's team at Soochow University used photocrosslinked microfluidics to prepare microspheres that provide a good growth microenvironment for bone marrow stromal stem cells to regenerate injectable osteogenic tissue. A related paper, "Injectable Stem Cell-Laden Photocrosslinkable Microspheres Fabricated Using Microfluidics for Rapid Generation of Osteogenic Tissue Constructs," was published in the journal Advanced Functional Materials.
Link to original article：https://doi.org/10.1002/adfm.201504943
Introduction: Nathaniel S. Hwang's team at Seoul National University, Korea, prepared PEGDA/MeCS-based composite hydrogels and obtained PEGDA-MeCS composite photocurable bioinks by methacrylating chondroitin sulfate for the study of biomineralization properties of gel scaffolds. The paper "Chondroitin Sulfate-Based Biomineralizing Surface Hydrogels for Bone Tissue Engineering" was published in the journal ACS Applied Materials & Interfacess.
Link to original article：https://doi.org/10.1021/acsami.7b04114
Copyright ©2022 Copyright: EFL-Tech Co.,Ltd, Suzhou, China 苏ICP备19070244号-1
Technical support: Wanhe Technology
